Yes, they have a week for this! It's National Clean Out Your Computer Week.

 
It's a great time to pause and take a few minutes to streamline your virtual workspace. Here are five great pointers:
  • Don't spend too much time deleting old files.  Memory space is cheap, certainly cheaper than the value of your time! If there are obvious things, then yes, delete them... but don't open up everything and examine it to decide whether to keep it, etc. If it's old and in your way, archive it to a DVD or move it to a folder where it won't be distracting.                                                                                                                                                                                                                                  
  • Keep your desktop clear. Delete unnecessary shortcut icons and add shortcuts that are really useful to you. Use the "Quick Launch" toolbar in XP, which puts frequently used icons where you can always see them. Click here or click this thumbnail screenshot for instructions on how to use the Quick Launch toolbar. If you use Quick Launch for a shortcut, you can delete that shortcut off the desktop, keeping it much less cluttered.                                                                                                                                           
  • Clean out your "My Documents" folder, creating new subfolders as needed to match up with your current projects and business structure.                                                                                               
  • Make sure you have a great backup system in place. Some good ones are www.carbonite.com and I personally use www.mozy.com.                                                               
  • Take a moment to check on running important utilities like spyware scans, virus scans, and defragmenting. This can really save you some heartache and even make your PC run better.                                                                                                                                  
  • Don’t use your Inbox as a file system. I use folders with my Outlook email so that at the end of each day I drag and drop to my Outlook folders Inbox items to remove them from the Inbox view. This gives me a clean Inbox start each day.
Always Remember:   Do. Delegate. Or Delete.   Now get out there!
Source: Living Order